SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope
Article Abstract:
Dynamic three-dimensional tracking of a single locus in live yeast shows that the activation of GAL genes leads to a confinement in dynamic motility and that the GAL locus is subject to sub-diffusive movement, which after activation can become constrained to a two-dimensional sliding motion along the nuclear envelope. RNA-fluorescence in situ hybridization analysis after activation reveals a higher transcriptional activity for the peripherally constrained GAL genes than for loci remaining intranuclear.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A switch for S phase
Article Abstract:
A seminal discovery about the identification of the protein factors from the budding yeast Saccharomyces cerevisiae that recognize the spots on DNA for initiating the DNA-replication phase of the cell cycle is reported. Phosphorylation is found to be at the heart of this intricate process, which is responsible for activation of two proteins known as Sld3 and Sld2 and the involvement of a third named Dpd11.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Stars in the making. Nobel laureate triumphs over loss of arm and returns to lab. Spare me the lecture
- Abstracts: Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily. Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins
- Abstracts: The APC/C and CBP/p300 cooperate to regulate transcription and cell cycle progression. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
- Abstracts: Monsoon rains start to ease India's drought. India pledges deluge of funds to water plan
- Abstracts: Counter-rotating microplates at the Galapagos triple junction. Geophysical evidence for reduced melt production on the Arctic ultraslow Gakkel mid-ocean ridge