Searching for FLASH domains
Article Abstract:
It is possible to raise doubts about research indicating that a protein named FLASH, required during programmed apoptosis to regulate the proteolytic cascade that leads to the death of the cell, is a functional analogue of mammalian Apaf-1 and its nematode homologue CED-4. Subsequent research was not able to identify any sequence similarity between FLASH and the Apaf-1/CED-4 or death-effector domain domains. Those responsible for the original research defend their work, but acknowledge that they may have overestimated the structural homology of FLASH with CED-4, even though these proteins are functionally homologous.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Article Abstract:
Cardif is a new caspase recruitment domains (CARD)-containing adaptor protein that interacts with RIG-I and recruits IKKbeta and IKKepsilon kinases by means of its C-terminal region, leading to the activation of NF(sub -kappaB) and IRF3. Cardif is targeted and inactivated by NS3-4A, a serine protease from hepatitis C virus, functioning as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Inhibition of death receptor signals by cellular FLIP
Article Abstract:
Scientists have identified a FLICE-inhibitory protein (FLIP) contained within muscle and lymphoid tissue which inhibits apoptosis. The short-form protein contains identical genetic sequences to viral FLIP inhibitors and has two death effector domains. The long-form protein has a caspase-like domain with an active-centre tyrosine residue. The research indicates that FLIP has a key role in tissue homeostatis and apoptosis regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Germline transmission of genetically modified primordial germ cells. Somatic control of germline sexual development is mediated by the JAK/STAT pathway
- Abstracts: Stabilization of the disk around [beta] Pictoris by extremely carbon-rich gas. Construction-site inspection
- Abstracts: Synergy in a superlattice. Don't mention the 'F' word: Raising brows. Changing face of the chameleon
- Abstracts: Impact origin of sediments at the Opportunity-landing site on Mars. The flow and ebb of water
- Abstracts: Evaluating temporal and spatial margins of safety in galahs. Individual, age and sex-specific information is contained in yellow-bellied marmot alarm calls