The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C.elegans
Article Abstract:
Insulin signalling in mammals controls glucose transport and the expression and activity of several metabolic enzymes. In the Caenorhabditis elegans nematode, a related pathway controls metabolism, development and longevity. The main role of DAF-2, a homologue of the mammalian insulin receptor, and AGE-1, a homologue of the catalytic subunit of phosphatidylinositol 3-OH kinase, signalling is to antagonize DAF-16. It is shown that null mutations in daf-16 suppress the effects of daf-2 or age-1 mutations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Casein kinase I transduces Wnt signals
Article Abstract:
It has been possible to identify gain-of-function, loss-of-function and biochemical evidence consistent with the view that the serine kinase casein kinase I (CKI) transduces Wnt signals. It is suggested that CKI is a conserved element of the Wnt signalling cascade and that CKI may function between dishevelled and GSK-3. It is possible that CKI is the kinase responsible for dishevelled phosphorylation rising in response to Wnt signalling, as it binds to and boosts the phosphorylation of dishevelled.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A molecular growth industry
Article Abstract:
The hormone pathway in the pituitary gland that controls growth has been investigated at the molecular level by two groups of researchers. They have found the pituitary receptor for the hypothalamic factor that induces the secretion of somatotropin (growth factor). This factor also induces the proliferation of the cells that secrete somatotropin. Both groups have managed to clone a genuine growth-hormone-releasing factor receptor. These findings could lead to treatments for dwarfism and gigantism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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