The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucelus

Article Abstract:

Transcription factor, kinase and replication factor movements between nucleus and cytoplasm are important in activity control. The way in which phosphorylation promotes protein export from the nucleus is not well understood. The export of the yeast transcription factor Pho4 was investigated to determine how it is regulated in response to alterations in phosphate availability. The importin-beta-family member MSn5 is the shuttling receptor used by Pho4 for nuclear export.

United States, Observations, Phosphorylation, Cell nuclei, Cell nucleus

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Cyclins in initiation

Article Abstract:

M. Wahi and A.D. Johnson have investigated the SRB genes and discovered that the SRB10 and SRB11 are actively involved in the phosphorylation of the II carboxy-terminal domain (CTD). The CTD is phylogenetically conserved and the SRB10 and SRB11 facilitate the conservation process. CTD are sometimes removed by deletion mutations that are lethal to cells. The SRB genes restrict the deletion mutations thereby enhancing the phylogenetic conservation of the CTD.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

Article Abstract:

Research on genetic regulatory networks indicates that peptide aptamers inhibit cyclin-dependent kinase 2 (Cdk2) activity by binding to a face of molecule and inhibiting its interaction with one of its partners. The aptamers are analogous to monoclonal antibodies and can serve as excellent alternatives to immunological reagents. A large number of aptamers can be generated from the combinatorial libraries and can be isolated together with their coding genes.

Analysis, Peptides, Protein binding

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