The essential bacterial cell-division protein FtsZ is a GTPase
Article Abstract:
Filamentary temperature sensitive protein Z (FtsZ) contributes to bacterial cytokinesis by binding and hydrolysing the GTP proteins. Cytokinesis is the final stage of cell division when cell constriction produces the daughter cells. FtsZ assists this process through GTP-dependent activation followed by the hydrolysis of GTP into GDP. Hence the GTP binding proteins and hydrolysis help FtsZ to open the way for bacterial cytokinesis, either by easing the formation of the FtsZ ring or by catalysing the cytokinesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein
Article Abstract:
The cellular division or septation of Escherichia coli (E. coli) involves the filamentation temperature sensitive Z (FtsZ) gene which binds the GTP protein in vitro by means of an unusual genetic sequence. In addition, a small amount of FtsZ functions as a separate membrane-linked species that likewise binds GTP. Hence FtsZ may be a GTP-activated signal transduction pathway for initiating septation in E. coli.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Traction forces of cytokinesis measured with optically modified elastic substrata
Article Abstract:
The forces governing the morphological changes that animal cells undergo when they divide in culture are examined. The silicone-rubber substratum method is extended to detect micronewtons and is used to quantitatively map the traction forces in cell division. Findings indicate that traction force can be observed locally at the cleavage furrow when no relaxation at the poles occurs during cleavage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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