Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Article Abstract:
It is shown that GABA mediate transmission suppression is mediated via endogenous cannabinoid release.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation
Article Abstract:
An investigation was conducted to elucidate the neurocircuitry of the mossy fibre pathway of the hippocampus. This pathway contains glutamate as a neurotransmitter as well as the opioid peptide dynorphin. The results showed that activation of mossy fibres which leads to the transmission of glutamate also generates a long-lasting inhibition of neighboring mossy fiber synapses by a presynaptic action of synaptically released dynorphin. This presynaptic inhibition was more pronounced in synapses expressing long-term potentiation. The results indicate that dynorphin has a physiological role in glutamatergic mossy fiber synapses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
Article Abstract:
Scientists have discovered that kainate neurotransmitter receptors activate the hippocampal mossy fibre pathway in synaptic transmission. A slow postsynaptic current has been identified at the kainate receptor and supports the theory that CA3 pyramidal cells have an excitatory role.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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