Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Article Abstract:
The strain of agent from cattle infected with bovine spongiform encephalopathy (BSE) gives a typical pattern of disease in mice that remains in place after experimental passage through several intermediate species. There is strong evidence that the same agent strain plays a role in both BSE and 'new variant' Creutzfeldt-Jakob disease (vCJD). It seems that the agent interacts with genetic factors in the host to control the timing and neuropathology of the disease with extreme precision. Transmissible spongiform encephalopathies carry some form of information that details strain-specific properties.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Mice and beef and brain diseases
Article Abstract:
Recent research by Collinge and colleagues suggests that the consumption of beef products contaminated with bovine spongiform encephalopathy (BSE) does not cause Creutzfeldt-Jakob disease (CJD). Analysis of non mutant mice and human prion protein (HuPrP) transgenic mice indicates a shorter survival time for HuPrP transgenic mice inoculated with CJD agent. The expression of HuPrP reduces the barrier to the transmission of CJD but has negligible influence on the incubation period after the BSE injection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Mice perform a human repertoire
Article Abstract:
A novel transgenic approach that integrates large sections of the human immunoglobulin transloci into the germ line of mice could facilitate the production of human monoclonal antibodies for therapeutic use. The approach exploits the natural diversification strategies of the mouse but has them operate on human immunoglobulin loci. Disruption of the mouse immunoglobulin loci allows the human transloci to perform unhampered by the endogenous loci.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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