Travelling by TRAM
Article Abstract:
A new endoplasmic reticulum (ER) membrane protein has been discovered that is probably part of the translocon or multicomponent translocation apparatus. Tom A. Rapoport and colleagues have broadened understanding of how proteins are transferred across the ER's membrane by isolating the new protein, called TRAM, which they found to be a glycoprotein contributing significantly to protein translocation. The research team demonstrated TRAM's vital role by showing that translocation stopped when TRAM was removed from the ER vesicles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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A new presentation pathway?
Article Abstract:
Two research groups demonstrated that peptides from defined signal sequences bind to the HLA-A2 class I molecule and that signal sequences are necessary for protein translocation into the endoplasmic reticulum's lumen. The groups, one with R.A. Henderson and others and the second with M.L. Wei and P. Cresswell, further showed that peptides that can bind to class I molecules can also get into the endoplasmic reticulum by the classical signal-dependent mechanism. Exactly how peptides enter the endoplasmic reticulum is uncertain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Membrane changes during hibernation
Article Abstract:
Issues are presented concerning the changes which occur in the endoplasmic reticulum membranes during a period of hibernation of ground squirrels. The phase behavior of membrane lipids is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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