p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
Article Abstract:
Functional loss of p73, which has high homology with the tumour suppressor p53 and with p63, a gene believed to be involved in the maintenance of epithelial stem cells, prompts the disappearance of the Cajal-Retzius (CR) neurons in the cortical marginal zone and hippocampal molecular layer in mice. This defect is the basis for the hippocampal dysgenesis present in p73-deficient mice. It appears that p73-dependent CR neurons produce factors apart from reelin to effect hippocampal neurogenesis. CR cells, which many people think control cortical neurogenesis, could instead have a key role in hippocampal development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Article Abstract:
Mice homozygous for a disrputed p63 gene, a homologue of the tumour-suppressor p53, show severe defects in skin, limb and craniofacial development. Defects in limb morphogenesis in p63 mutants are seen as early as E9.5 and progress through to E12, a time of limb-bud formation determined by ectodermal-mesenchymal signalling interactions. There is a strong link between p63 expression in epithelial progenitor cells and its absolute requirement in the undisrupted development of stratified squamous epithelia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Article Abstract:
Research indicates that the regulatory N-methyl-D-aspartate subunit (NR3A) is an integral part of the biochemical reaction that modulates the glutamate receptor N-methyl-D-aspartate (NMDA). Experiments using mice deficient in NR3A established an enhanced NMDA response and increased NMDA current spine density in P19 Purkinje cells and adult cerebrocortical cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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