A versatile transcriptional effector of wingless signaling
Article Abstract:
Recent evidence shows that Arm (armadillo gene product) protein, an integral part of Wingless (wg) signaling in Drosophila sp., also acts as an activator of transcription of mutational messages to the nucleus in addition to its role in forming protein-binding complexes needed in building cytoskeletal structures. TCF (T cell factors) protein, a DNA-bound transcriptional activators, interact with Arm protein which in turn, gives access to the terminus that give the same segment polarity phenotype as that of wg. To activate the arm's transcriptional factor, there should be an increase in the cytoplasmic concentration of free Arm molecules in order to bind to TCF.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Powered by gas-A ligand for a fruit fly nuclear receptor
Article Abstract:
The fruit fly E75 nuclear receptor contains heme in its ligand binding pocket. Study is conducted on how heme, gas signaling and nuclear receptors interact to control metabolic and developmental pathways.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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