Genetic regulation of nitrogen metabolism in the fungi

Article Abstract:

A study was conducted to determine the regulatory mechanisms involved in genetically regulating nitrogen metabolism of Saccharomyces cerevisiae, Aspergillus nidulans and Neurospora crassa. Experimental results show that nitrogen catabolite repression is induced by positive-acting transcription factors of the GATA family of proteins. It was also noted that the regulation within the nitrogen circuit involves specific protein-protein interactions, as shown by the specific binding of the negative-acting NMR protein with the positive-acting NIT2 protein of Neurospora crassa.

Aspergillus, Nitrogen metabolism, Neurospora, Saccharomyces cerevisiae

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Regulation of X-chromosome inactivation in development in mice and humans

Article Abstract:

A study was conducted on the X-chromosome inactivation (XCI) to determine its mechanisms and the functions of an X-linked regulatory gene, Xist, in the development in mice and humans. Results showed that the regulation of XCI depends on the Xist gene regulation, which is regulated by DNA methylation. This indicates that the differential methylation of the Xist gene is the most probable mechanism regulating the imprinted paternal XCI in extraembryonic tissues and the paternal allele's imprinted preferential expression in preimplantation embryos.

Human beings, Mice, Mice (Rodents), Humans, X chromosome

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Imprinted expression of SNRPN in human preimplantation embryos

Article Abstract:

The SNRPN gene is key to the imprinting-center regulation process of preimplantation embryos. Two neurogenetic disorders, Angelman syndrome and Prader-Willi syndrome, can be determined by analyzing for the absence or presence of this gene. This can be done through using single-cell-sensitive procedures to detect SNRPN as early as the four-cell stage of embryonic development.

United States, Genetic disorders, Neurogenetics, Embryology, Human, Human embryology

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