The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance

Article Abstract:

Multidrug-resistant strains of Mycobacterium tuberculosis threaten the world's tuberculosis-control programs. Mutations in the inhA gene, encoding a target for isoniazid (INH) and its analogue ethionamide (ETH), have been shown to confer resistance to INH and ETH in drug-resistant M. tuberculosis. MabA may be an additional target for INH and ETH. the MabA-encoded activity was characterized to examine whether it can be a target for INH and ETH. Expression in Escherichia colin showed a 3-ketoacyl reductase activity.

Tuberculosis, Mycobacterium tuberculosis, Isoniazid

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Determination of a 15447 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs

Article Abstract:

The cloning and sequencing of a 15437 bp region incorporating the inhA locus from the Mycobacterium avium chromosome was undertaken. The region ws found to contain acnA, fabG, inhA and hemH genes, and invA and invB genes showing homology with p60 invasion protein of Listeria monocytogenes. An RGD motif was contained in six proteins encoded by putative ORFs, with other putative products encoded by ORFs showing little homology with proteins included in the databases.

Physiological aspects, Observations, Nucleotide sequence, Base sequence, Mycobacterium avium

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Is1626, a new IS900-related Mycobacterium avium insertion sequence

Article Abstract:

Research was conducted to characterize the chromosomal insertion sequence IS1626 from a bacterial species. Results show that IS1626 is a 1418 base pair long with 65 mol% of G+C content and without terminal inverted or flanking direct repeats.

Canada, Analysis, Usage, DNA probes, Evolution (Biology), Microorganisms, Translocation (Genetics), Insertion elements, DNA, DNA insertion elements

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