RNase III cleaves eukaryotic preribosomal RNA at a U3 snoRNP-dependent site
Article Abstract:
The machinery for the production of ribosomal RNA includes the small nucleolar ribonucleoprotein particles (snoRNPs), which contain the small nucleolar RNAs (snoRNAs) associated with proteins. In Saccharomyces cerevisiae, expression of its gene analogous to bacterial RNase III (RNT1) produces a double-strand specific endoribonuclease. This protein acts to cleave the 5'-external transcribed spacers (ETS) RNA at the AO site, while cleaving a 3'-ETS substrate at site 21 nt downstream of the 3' end of the 28S rRNA.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Concepts in nuclear architecture
Article Abstract:
An overview of some of the emerging concepts in the study of in vivo genome organization and function is described. The complete clarification of the contribution that nuclear architecture makes to gene expression will be needed to understand physiological processes such as differentiation, development and disease at cellular level.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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