Making the connection: cytoskeletal rearrangements during growth cone guidance
Article Abstract:
A three-stage model to explain the role of the cytoskeleton during axonal guidance is presented. The first stage shows the interaction between growth cones and environmental cues such as movements of filopodia and lamella, which are controlled by actin filaments. The second stage shows the influence of these actin protrusions on growth cone orientation and motility in an intracellular environment created by microtubules. The third stage shows the role of microtubules in the formation of an axon tube in a selected site.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Axon membrane flows from the growth cone to the cell body
Article Abstract:
The axon membrane moves from the growth cone to the cell body by endocytosis during neuron growth in the chick dorsal root ganglion. A difference in the membrane tension between the growth cone and the cell body maintains the high rate of flow. Brefeldin A which inhibits anterograde transport in the axons suppresses the membrane flow. The membrane flow replenishes the axon membrane by exchanging the components of the plasma membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages
Article Abstract:
The sampling and response of cells to the rigidity of the anchoring cellular matrix is investigated. An optical trap on fibroblasts is used to mimic extracellular attachment sites of various resistance. The strength of integrin-cytoskeleton linkages is found to be dependent on matrix rigidity and on its biochemical composition. Matrix rigidity may thus be employed as a guide for mechanotaxis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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