Mapping tumor-suppressor genes with multipoint statistics from copy-number-variation data
Article Abstract:
An algorithm that estimates the location of tumor-suppressor genes (TSGs) is proposed by analyzing segmental deletions in the genomes of patients with cancer and spatial relation of the deleted segments to any specific genomic interval. It is discussed how, with suitable modifications to the underlying modifications to the underlying statistical model, this algorithm could be applied generally to a wider class of problems.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Variance calculations for identity-by-descent estimation
Article Abstract:
Nonparametric linkage strategies often involve estimation of identity by descent (IBD) with the use of affected sibling pairs. Methods for IBD estimation are well established and are successful for mapping complex traits.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100k scan
Article Abstract:
A novel two-stage strategy that weighs the association p values with the use of independently estimated weights is proposed and concluded that this strategy helps in genomewide association studies.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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