Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein
Article Abstract:
A novel beta-catenin-interacting protein, ICAT, has been identified. It has been found to inhibit interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated transactivation. ICAT inhibits Xenopus axis formation in that it interferes with Wnt signaling. It appears likely that ICAT negatively regulates Wnt signaling by inhibition of the interaction of beta-catenin with TCF. It is also integral in development and cell proliferation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
Article Abstract:
Multiple Ras-dependent phosphorylation pathways have been found to regulate Myc protein stability. Two N-terminal phosphorylation sites in Myc , Thr 58 and Ser 62 were investigated. A synergistic role for multiple Ras-mediated phosphorylation pathways in the control of Myc protein accumulation during the first stage of cell proliferation has been defined.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(super.SEI-1)
Article Abstract:
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(super.SEI-1), is discussed. The p16(super.INK4a) tumor suppressor works against cyclin-dependent kinases, CDK6 and CDK4. The novel gene SEI-1, the product of which seems to work against the function of p16(super.INK4a), has been isolated.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha
- Abstracts: Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Guidance of cell migration by the Drosophila PDGF/VEGF receptor
- Abstracts: Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Generation of superhelical torsion by ATP-dependent chromatin remodeling activities
- Abstracts: Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila. Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs
- Abstracts: Additive and non-additive genetic architecture of two different-sized populations of Scabiosa canescens. Genetic structure in the nonrewarding, bumblebee-pollinated orchid Calypso bulbosa