Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
Article Abstract:
Research concerning the chronic faults that emerge in hematopoiesis for mice, homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6, focussed on testing whether the faults at the me locus could be due to mutations inside the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. The similar map positions of the Hcph and me loci and the believable function of hematopoietic cell phosphatase (HCP) as a decisive signaling molecule in hematopoietic cell control and development prompted this focus. The me and mev mutations were inside the Hcph gene.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Smads: transcriptional activators of TGF-beta responses
Article Abstract:
The transforming growth factor-beta superfamily of polypeptides have intracellular signaling mediators called Smads. These membrane proteins exhibit two large conservative domains, the MH1 or N domain and the MH2 or C domain, divided by a conserved linker segment. Smads function as type I receptor-activated signaling effectors regulating transcription of discriminate genes in reaction to ligand. The mechanism involved in the transcriptional stimulation of Smads is denoted by the combined requirements for interactions with other transcription factors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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STATs: signal transducers and activators of transcription
Article Abstract:
Signal transducers and activators of transcription (STATs) are DNA-binding proteins that were first identified in mammalian genes. Genetic mapping studies suggest that the structure of STATs are related to their function in the cell. STATs possess a conserved region that has a potential for phosphotyrosine-binding. They also contain a highly divergent carboxy-terminal domain that influences transcriptional activation. They may also form heterodimeric complexes to bind cytokines.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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