New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB

Article Abstract:

A sequence element just upstream from the TATA element has the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3'. It affects ability of transcription factor IIB to go into transcription complexes and to support initiation of transcription. A fourth core promoter element, the IIB recognition element (BRE), is a factor in transcription initiation. Also involved are the TATA element, the initiator element and the downstream promoter element. A second sequence-specific general transcription factor, IIB, is involved, as is transcription factor IID.

Promoters (Genetics), RNA polymerases, Cell receptors, DNA binding proteins

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The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription

Article Abstract:

RBP is a cellular protein that specifically targets TFIID and TFIIA coactivators to repress transcription in mammalian cells. RBP interacts with these transcriptional coactivators to disrupt their optimal interaction. The resultant repression can be prevented if stable transcription preinitiation happens before RBP interaction.

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Reconstitution of recombinant chromatin establishes a recruitment for histone-tail modifications during chromatin assembly and transcription

Article Abstract:

Results show that histone-tail modifications regulate transcription from the recombinant chromatin. Data reveal that acetylation of the histone tail increases transcription, while methylation represses it.

United States, Analysis, Physiological aspects, Nucleoproteins, Chromatin, Structure-activity relationships (Biochemistry)

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