SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium
Article Abstract:
The prestalk cell differentiation in Dictyostelium is caused by TTGA-binding factor which is a transcriptional regulator activated by DIF. In the research, it is shown that the TTGA-binding factor is a STAT protein which is similar to metazoan STATs that performs through mutual interaction of a phosphotyrosine residue on one molecule with an SH2 domain on a dimerizing partner. Through the experiments, the SH2 signaling pathways is believed to have sprung earlier in the development of multicellular organisms to aid intercellular communication.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase
Article Abstract:
A study shows that Mnd2, a factor known to associate with Anaphase-Promoting Complex (APC) components, prevents premature securing degradation in meiosis by APC. Results showed that Mnd2 was identified in a yeast screen, in which genes that are unregulated in meiosis were systematically deleted and tested for chromosome segregation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama 1
Article Abstract:
A study shows that Mnd2, a subunit of the anaphase-promoting complex (APC/C) from budding yeast, is essential to prevent premature destruction of cohesion in meiosis. It is concluded that chromosome segregation in meiosis depends on the selective inhibition of a meiosis-specific form of the APC/C.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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