SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression
Article Abstract:
A novel cell type-specific matrix attachment region (MAR)-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin mu locus in pre-B cells and enhances gene expression, is characterized. It is found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIASI
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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LEF1-mediated regulation of Delta-like 1 links Wnt and Notch signaling lin somitogenesis
Article Abstract:
A molecular basis for the presumed hierarchy of placing WNT signaling upstream of the Notch pathway in vertebrate somitogenesis is examined. It is shown that a targeted mutation of Lef1, which abrogates LEF1 function and impairs the activity of coexpressed TCF factors, affects the patterning of somites and the expression of components of the Notch pathway.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Dynamics and interplay of nuclear architecture, genome organization, and gene expression
Article Abstract:
Studies that have provided exiting insights into the interplay between nuclear architecture, genome organization and gene expression in a cell are discussed. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangements of genomic sequences, help carry out and regulate nuclear processes.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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