The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

Article Abstract:

The human Tap protein is a nuclear mRNA export factor containing novel RNA-binding and nucleocytoplasmic transport sequences. Quail cells are refractory to consitutive transport element (CTE) function, although they are highly permissive when expression of the human Tap protein takes place. The protein is a candidate CTE cofactor. Tap has a novel sequence-specific RNA binding domain sufficient for CTE binding but not to support CTE function. Two nuclear localization signals (NLSs) and one nuclear export signal (NES) have been defined in Tap. A novel type of NES that is able to support nuclear mRNA export but that does not act through Crm1 has been validated.

United States, Proteins, Cellular signal transduction, Cell nuclei, Cell nucleus, Nuclear membranes, Nuclear membrane, Heredity, Human, Human heredity

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State-dependent Ras signalling and AMPA receptor trafficking

Article Abstract:

Study is conducted to show that low levels of Ras activity stimulate extracellular signal-regulated kinase kinase (MEK)-p42/44 MAPK (extracellular signal-regulated kinase B [ERK] signaling), whereas high levels of Ras activity stimulate additional Pi3 kinase (Pi3K)-protein kinase B (PKB) signaling. Ras-MEK-ERK activity in sleeping animals is sufficient to deliver GluR2L into synapses, while additional increased Ras-Pi3K-PKB activity in awaken animals delivers GluR1 synapses

Germany, Influence, Adaptation (Physiology), Physiological adaptation, Phosphorylation, Neural transmission, Synaptic transmission, Cognition in children, Cognitive development

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

Article Abstract:

It is demonstrated that human pre-miRNA nuclear export, and miRNA function, are dependent on Exportin-5. The findings show that Exportin-5 can bind pre-miRNAs specifically in vitro, but only in the presence of the Ran-GTP cofactor.

GTP, Guanosine triphosphate

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