Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled
Article Abstract:
The four-step His-Asp-His-Asp phosphorelay is a complicated signaling pathway derived from the already complex two-component regulatory system. In 1991, the first phosphorelay system was identified in the initial sporulation step of Bacillus subtilis. Reports of analogous two-step pathways have emerged more recently. A 1996 report deals with a His-Asp-His-Asp phosphorelay in the osmoregulation of Saccharomyces cerevisiae. This provides the first evidence of a typical bacterial phosphorylation reaction among proteins of eukaryotic two-component species.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
Article Abstract:
A multi-step phosphorelay signal pathway is demonstrated in the osmoregulatory control mechanism of Saccharomyces cerevisiae. The three-protein mechanism, Sln1p, Ypd1p and Ssk1p, controls a three-tiered MAP kinase cascade. The three protein kinases are SSK2 and SSK22 MAP kinase kinase kinases, PBS2 MAP kinase kinase and high osmolarity glycerol response (HOG1) MAPK. The system starts with the autophosphorylation of Sln1p at His576. This is followed by phosphate transfer to Sln1p-Asp1144, Ypd1p-His 64 and Ssk1p-Asp554, respectively.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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His-Asp phosphorelay: two components or more?
Article Abstract:
The book 'Two-Component Signal Transduction' provides an up-to-date compilation of research done on the signal transduction system in prokaryotes that utilizes the reversible histidine-aspartate phosphorelay system, the so-called 'two-component' system. Researchers are made to note that the signal pathway has been shown to consist of several components in recent researches and that nomenclature in this field of research needs to be systematized. The book is considered an excellent material for researchers in signal transduction.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
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