The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development
Article Abstract:
A Caenorhabditis elegans gene, ptp-2, has been characterized. It encodes a 668-amino acid protein tyrosine phosphatase (SHP). A recessive ptp-2 loss-of-function allele, op194, lacking the conserved protein tyrosine phosphatase (PTP) catalytic domain has been isolated. Certain phenotypes show that PTP-2 activity is needed for proper oogenesis. PTP-2 function in C. elegans vulval cell differentiation seems to be directed at regulating overall strength of the inductive signal, which may contribute to the quantitative differences in signaling needed for specification of vulval cell fates.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
Article Abstract:
A neurosecretory pathway controls a reversible developmental arrest and metabolic shift in the dauer larval stage of Caenorhabditis elegans. Defects in a signaling pathway like that of insulin cause arrest. Akt/PKB transduces signals like those of an insulin receptor to the DAF-16 transcription factor from AGE-1 PI3 kinase.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
A requirement for NF-kB activation in Bcr-Abl-mediated transformation
Article Abstract:
NF-kB is an important factor in Bcr-Abl signaling. It is likely that Bcr-Abl transformation and affected leukemias are affected by NF-kb modified genes.The experiment proves that NF-kB is needed for Bcr-Abl-mediated tumorigenicity in nude mic and for transformation of primary bone marrow cells.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
- Abstracts: Aging of C. elegans: Mosaics and mechanisms. 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae
- Abstracts: The origins of V(D)J recombination. Evolution of simple repeats in DNA and their relation to human disease
- Abstracts: Metabolism of inositol 1,4,5-triphosphate in Candida albicans: significance as a precursor of inositol polyphosphates and in signal transduction during the dimorphic transition from yeast cells to germ tubes
- Abstracts: Interspecies approaches for the analysis of parental imprinting during mouse development. Interspecific and extraspecific pregnancies in equids: anything goes