Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120
Article Abstract:
Research has been conducted on HIV-1 coreceptor CCR5. The role of sulfated tyrosines in this receptor has been investigated, and the results demonstrate that the primary receptor CD4-induced HIV-1 nutralizing antibodies emulate CCR5, and that tyrosine sulfation contributes to the potency of the human humoral response.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
CCR5 mimicry by sulfated human anti-HIV-1 antibodies
Article Abstract:
The authors discuss the study on HIV-1 envelope glycoprotein which requires sulfated tyrosines on the CCR5 amino terminus during its interaction with coreceptor CCR5. The topics of interest include the analysis of tyrosine-sulfated neutralizing antibodies against HIV-1 which mimics CCR5.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparin sulfate proteoglycans
Article Abstract:
Research has been conducted on the vaccinia virus complement control protein inhibiting the complement activation pathways. Results indicate that the structure of the complement regulation intact regulator will stimulate the design of the therapeutic complement inhibitors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Identification of genes involved in the activation of the Bacillus thuringiensis inhA metalloprotease gene at the onset of sporulation
- Abstracts: The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes
- Abstracts: The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress
- Abstracts: Structural and functional analysis of the mitotic rotamase pin1 suggests substrate recognition is phosphorylation dependent
- Abstracts: Tumor induction and tissue atrophy in mice lacking E2F-1. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor