mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3prime end
Article Abstract:
Two proteins that bind to the differentiation control element (DICE) were purified from rabbit reticulocytes and analyzed to characterize their role in erythroid differentiation and messenger RNA (mRNA) silencing. The two DICE-binding proteins designated as, hnRNP K and hnRNP E1 silenced internal ribosomal entry site- and cap-dependent translation by preventing the assembly of 80S ribosomes. Furthermore, hnRNP K and hnRNP E1 acted as specific cytoplasmic regulatory protein components of 15-lipoxygenase messenger RNA translation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site
Article Abstract:
Research has been conducted on toxin-antitoxin pair RelE-RelB encoded by Escherichia coli relB operon. Results demonstrate that RelE cleaves mRNA in the ribosomal A site with high codon specificity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Antagonistic interactions among marine bacteria impede the proliferation of Vibrio cholerae. Dynamics of bacterial community composition and activity during a mesocosm diatom bloom
- Abstracts: Quantitative genetics of female choice in an ultrasonic pyralid moth, Achroia grisella: variation and evolvability of preference along multiple dimensions of the male advertisement signal
- Abstracts: Mapping AFLP markers associated with subspecific differentiation of Oryza sativa (rice) and an investigation of segregation distortion
- Abstracts: Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
- Abstracts: Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity