A critical new pathway for toxin secretion?
Article Abstract:
Five specialized protein secretion systems are essential for the virulence of many bacterial pathogens. The identification of a sixth toxin secretion pathway discovered in Vibrio cholerae that causes cholera and Pseudomonas aeruginosa responsible for cystic fibrosis enables an important potential target for vaccine development and for therapeutic interventions aimed at disrupting the type VI activity of toxin secretion.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Disarming pathogens - A new approach for antibiotic development
Article Abstract:
The antibiotics presently in use are bacteriostatic or bacteriocidal, which work by inhibiting bacterial processes, like protein synthesis or DNA replication essential for cell growth. Since antivirulence drug would not ordinarily inhibit the growth of pathogens, they might facilitate the development of immune, responses that would prevent subsequent infection.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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