An 18-year-old woman with hepatomegaly and ascites

Article Abstract:

A previously healthy 18 year-old-woman admitted to the hospital with abdominal bloating and ascites was found to have Budd-Chiari syndrome, and later received a liver transplant. Budd-Chiari syndrome is a disorder of the liver, characterized by an obstruction of the veins in the liver that leads to enlargement of the organ, coupled with increasing blood pressure in the region. A thrombus was located in one of the woman's hepatic veins, and a liver biopsy revealed sinusoidal dilation and congestion, both typical of the syndrome. Budd-Chiari syndrome is often associated with pregnancy or the use of oral contraceptives by women, but hereditary factors predisposing a person to thrombosis are also associated with the condition. The woman in question had a congenital protein C deficiency, which predisposed her to thrombosis.

Diagnosis, Hepatic vein thrombosis, Budd-Chiari syndrome

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Fulminant liver failure in association with the emetic toxin of Bacillus cereus

Article Abstract:

A 17-year-old boy died from liver failure after eating spaghetti contaminated with the bacterium Bacillus cereus. He and his father had re-heated the spaghetti and developed symptoms of food poisoning 30 minutes after eating it. The father eventually recovered, but the boy was hospitalized with liver failure and died. Samples of his liver and the spaghetti sauce were found to contain the bacterium, which produces a toxin that can affect cell mitochondria. Inhibition of fatty acid metabolism in mitochondria could explain the pathologic changes in his liver.

Health aspects, Cooking, Cookery (Pasta), Pasta products, Bacterial toxins, Contamination

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A 28-year-old man with gram-negative sepsis of uncertain cause

Article Abstract:

A 28-year-old man was admitted to a hospital with fever, headache, fatigue, loss of appetite and difficulty concentrating. Analysis of blood samples revealed that he had a bacterial infection. His doctors suspected gastrointestinal infection with Salmonella typhi, which causes typhoid fever, because he had many symptoms of typhoid fever. Cultures of his blood samples grew Salmonella typhi. He was treated fluoroquinolone antibiotics and recovered.

Case studies, Typhoid fever

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