Anti-inflammatory therapy reduces wheezing after bronchiolitis

Article Abstract:

Treatment with the anti-inflammatory drugs budesonide or cromolyn sodium in aerosol form appears to reduce the number of hospital admissions and in-hospital wheezing episodes in infants with bronchiolitis. Researchers compared the effects of a high concentration 8-week treatment with either budesonide or cromolyn sodium followed by a low concentration 8-week treatment against no treatment (the control group) in 92 infants with bronchiolitis. Patients treated with budesonide had proportionally fewer in-hospital wheezing episodes (10%) than those treated with cromolyn sodium (19%) or no treatment (40%) during the second 8-week study period. Drug treatment did not reduce the overall frequency of symptoms but relieved the symptoms more quickly and reduced the need for additional medication. Patients in the treatment groups who also had allergies required fewer hospitalizations and had fewer in-hospital wheezing episodes than the controls with allergies.

Evaluation, Drug therapy, Wheeze, Wheezing, Anti-inflammatory drugs, Anti-inflammatory agents

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The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis

Article Abstract:

Inhaled epinephrine appears to be superior to inhaled albuterol in relieving breathing difficulties in young children with bronchiolitis. However, air moistened with saline also relieved symptoms. Bronchiolitis is an acute viral inflammation of the breathing passages which can cause them to swell shut, obstructing breathing. One hundred children younger than 24 months who were admitted to the hospital with wheezing and respiratory distress were randomly assigned to one of the following procedures: inhaled epinephrine followed 30 minutes later by salt water mist; albuterol followed by salt water mist; salt water followed by epinephrine; or salt water followed by albuterol. Symptoms of respiratory distress were scored as were changes in score after treatment. Salt water mist and both medications resulted in decrease of respiratory symptoms, but epinephrine showed the greatest effect. No significant side effects were seen in any group.

Health aspects, Care and treatment, Respiratory distress syndrome, Albuterol

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A 2-to-3-year outcome after bronchiolitis

Article Abstract:

Children hospitalized with bronchiolitis are more likely to have recurrent wheezing episodes than children hospitalized with childhood pneumonia. This is true even when the respiratory problems are caused by the same bacteria or virus. Of 127 children under two years old who were hospitalized in Finland for either wheezing or pneumonia, 108 were followed until they were three years old. Recurrent wheezing occurred in 76% of the one to two year olds previously hospitalized for wheezing. Only 9% of the children treated for pneumonia experienced a recurrence of wheezing at the same age. Other environmental and genetic factors were examined, but no significant differences were found between the family histories of the two groups.

Prognosis, Pneumonia in children, Childhood pneumonia

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