Cigarette smoking and progression of atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study
Article Abstract:
Both cigarette smoking and exposure to second-hand smoke appear to increase the progression of atherosclerosis. Atherosclerosis is characterized by a build-up of fatty deposits in the arteries. Researchers used ultrasound scans of the carotid arteries in the neck to determine the progression of atherosclerosis in 10,914 people. Smoking increased the progression of atherosclerosis in the arteries 50% and a history of past smoking increased it by 25%. Exposure to second-hand smoke increased atherosclerosis progression by 20%. Diabetics and those with hypertension were especially susceptible.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
Article Abstract:
A trial is conducted to test if torcetrapib, an inhibitor of cholesteryl ester transfer protein can minimize atherosclerotic vascular disease by raising the levels of high-density lipoprotein (HDL) cholesterol in 850 patients with heterozygous familial hypercholesterolemia. It is concluded that use of torcetrapib with atorvastatin, did not reduce the progress of atherosclerosis, inspite of substantial, rise in the level of HDL cholesterol and reduction the LDL cholesterol and triglycerides level.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
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Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: The METEOR trial
Article Abstract:
A study was conducted to assess whether statin therapy could slow progression and cause regression of carotid intima-media thickness (CIMT) over two years. Findings demonstrated that in middle-aged adults with Framingham risk scores of less than 10%, and evidence of subclinical atherosclerosis, rosuvastatin resulted in significant reductions in the rate of progression of maximum CIMT over two years vs. placebo.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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