Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Article Abstract:
The proteases tryptase and trypsin stimulate proteinase-activated receptor 2 (PAR2) on sensory nerves. The nerves then release pro-inflammatory neuropeptides such as calcitonin gene-related peptide and substance P.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway
Article Abstract:
Research has disclosed a new nociceptive pathway that indicates a direct role for proteinases and their receptors in the mechanism of pain transmission. The key finding in this study shows that neurokinin-1 receptor expressed hyperalgesia has been induced by proteinase-activated receptor-2.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions
Article Abstract:
The studies showed that protease activated receptor 2 (PAR-2) expression is enhanced in human coronary atherosclerotic lesions from humans with no classic risk factors for atherosclerosis. The pharmacological study establishes whether modulation of PAR-2 represents a possible therapeutic target for controlling the vascular response injury.
Publication Name: Journal of Clinical Pathology
Subject: Health
ISSN: 0021-9746
Year: 2004
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