Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Article Abstract:
Activation of the canonical Wnt pathway is sufficient to maintain self-renewal of Human and mouse embryonic stem cells. Results recommend the use of glycogen synthase kinase-3 (GSK-3) specific inhibitors such as 6-bromoindirubin-3'-oxime (BIO) may have practical applications in regenerative medicine.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Developmental regulation of the growth plate
Article Abstract:
The increase in understanding of the signaling pathways and the transcription factors that control endochondrol bone development is examined. Several intensively studied signaling system and transcription factors to illustrate the logic of the molecular regulation of bone formation are focused.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Transcriptional analysis of targets in multiple sclerosis
Article Abstract:
New approaches that use transcriptional analysis are being developed for identifying new targets that can be exploited for controlling multiple sclerosis. The large-scale approaches can be utilized in proteomics and in understanding the complexities involved in autoimmune inflammation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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