Pathophysiology of premature skin aging induced by ultraviolet light

Article Abstract:

Skin aging associated with prolonged sun exposure may be the result of an induction of substances that destroy collagen and might be prevented by pre-treatment with topical tretinoin. Fifty-nine white individuals were exposed to ultraviolet light on their buttocks, and skin biopsies of irradiated and non-irradiated areas were taken. Some of the patients were pre-treated with tretinoin before irradiation. The production of matrix-degrading metalloproteinases, which dissolve collagen, was accelerated by irradiation and sustained with multiple exposures. Tretinoin prevented this stimulation. Theoretically, this destruction of collagen and its imperfect repair could result in wrinkling.

Measurement, Ultraviolet radiation, Skin, Collagen, Metalloenzymes, Radiation effects, Skin, Effect of radiation on the

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The pathophysiology of acquired aplastic anemia

Article Abstract:

Aplastic anemia can be successfully treated but its exact cause is still unknown. It is characterized by a failure of the bone marrow to produce blood cells, including red and white blood cells. Even stem cells, which are the precursor of all blood cells, are affected. A recovery of the bone marrow after immunosuppressive therapy led to the discovery that aplastic anemia may be an autoimmune disease. The exact agent that triggers the autoimmunity is not known, but aplastic anemia can be caused by drugs, viruses and other infectious agents. It can be treated with immunosuppressive drugs.

Aplastic anemia

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Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis

Article Abstract:

Residual cells from a fetus may be involved in the autoimmune disease systemic sclerosis. Systemic sclerosis is a connective-tissue condition which causes skin lesions and other symptoms, and is far more common in women than men. Researchers tested blood and skin lesion samples from 69 women with the disease and 25 healthy women. Y-chromosome (male) DNA was detected in 46% of blood samples and 58% of skin samples from women with systemic sclerosis. Very few healthy women had detectable Y-chromosome DNA. Fetal cells may initiate an immune reaction which is related to the disease.

Health aspects, Maternal-fetal exchange, Systemic scleroderma, Scleroderma (Disease), Graft versus host reaction, Graft vs. host disease, Fetal tissues

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