Automated real-time immunoassay of biomolecules

Article Abstract:

ImmunoDetection (ID) is a new automated method for separating biomolecules that incorporates both liquid chromatography (LC) and immunoassay technology. Like LC, ID uses the differential migration of molecules through a packed column of particles to achieve separation. Like immunoassay, ID uses the binding properties of antibodies to achieve separation. ID is superior to conventional methods in four ways: it is more exact, has a wider dynamic range, can be directly calibrated and allows for a more efficient removal of non-target solutes.

Innovations, Biomolecules, High performance liquid chromatography, Antibodies

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Total synthesis of the potential anticancer vaccine KH-1 adenocarcinoma antigen

Article Abstract:

Scientists have developed a technique to artificially synthesise the KH-1 adenocarcinoma antigen and a bioconjugatable analogue capable of binding to carrier protein. The technique could be modified to synthesise other carbohydrate antigens for future anticancer vaccine development. The synthesized product's structure was verified using nuclear magnetic resonance analysis and mass spectroscopy.

Biosynthesis, Adenocarcinoma

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Diagnosis on disc

Article Abstract:

Highly complex immunoassays that identify and quantify many different antigens simultaneously need high-resolution imaging capability. An immunoassay readout of high efficiency and sensitivity, using, in a slightly modified form, a pick-up head of a compact-disc player is both elegant, simple and cost effective.

Household audio and video equipment, Audio and Video Equipment Manufacturing, Science & research, Digital Audio Disc Players, Methods, Compact disc players, Compact disc players and recorders, Compact disc changers

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