DNA sequences and analysis of human chromosome 18
Article Abstract:
The finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of the chromosome, is reported. Despite the low density of protein-coding genes on chromosome 18, it is found that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to he genome-wide average.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions
Article Abstract:
The clustered genes of the Hox family of homeobox proteins play an important role in embryonic development and proliferation. It is found that murine geminin associates transiently with members of the Hox-repressing polycomb complex, with the chromatin of Hox regulatory DNA elements and with Hox proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Reproduction in clusters
Article Abstract:
Homeobox genes consist of a characteristic DNA sequence and are essential for the numerous aspects of embryonic development. The clustering of the homeobox genes help in determining their spatial and temporal regulation and also, details of the 12 reproductive homeobox X-linked (Rhox) genes are given.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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