Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1
Article Abstract:
It has been established that immature erythroid cells express a number of death receptors whose ligands are produced by mature erythroblasts. Interaction between death receptors and their ligands leads to caspase-mediated degradation of the transcription factor GATA-1 and blockade of erythropoiesis. It is suggested that caspases cause the arrest of erythroid differentiation through cleavage of GATA-1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Differential modulation of endotoxin responsiveness by uman caspase-12 polymorphisms
Article Abstract:
The single nucleotide polymorphism encoding caspase proenzyme (Csp 12-L) in populations of African descent is examined. Caspase 12-L is responsible for attenuating the inflammatory and innate immune response to endotoxins and the frequency of Csp 12-L allele increases in African American individuals with severe sepsis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
Article Abstract:
A novel role for a caspase is described in dampening responses to d. It is shown that in mice, gene-targeted deletion of caspase-12 renders animals resistant to peritonitis and septic shock.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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