Reassembly of shattered chromosomes in Deinococcus radiodurans
Article Abstract:
The relevant two-stage DNA repair process which involves an unknown molecular mechanism for fragment reassembly called 'extended synthesis-dependent strand annealing' (ESDSA), followed and completed by crossovers is described. It is found that intermediates require RecA-dependent crossovers to mature into circular chromosomes that comprise double-stranded patchworks of numerous DNA blocks synthesized before radiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Enzymes of evolutionary change
Article Abstract:
New reports show how genetic diversification needs to be a continuous process. Tang and colleagues and Bacher Reuven and colleagues suggest that a nucleoprotein filament is not a good substrate for elongation by the DNA polymerase III holoenzyme, and that the RecA filament appears to be the only substrate for the DNA polymerase V mutase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Fidelity and infidelity
Article Abstract:
Issues concerning the fidelity of molecular processes are discussed. Nature puts errors and infidelity to positive effect, allowing continuous adaptation to new environmental circumstances.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Assembly of submicrometre ferromagnets in gallium arsenide semiconductors. Teaching magnets new tricks
- Abstracts: Peripheral deletion of antigen-reactive T cells in oral tolerance. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
- Abstracts: Observation of Feshbach resonances in a Bose-Einstein condensate. Skyrmions in a ferromagnetic Bose-Einstein condensate
- Abstracts: A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
- Abstracts: Rubber hands 'feel' touch that eyes see. Action plans used in action observation. Feeling bumps and holes