Time-dependent reorganization of brain circuity underlying long-term memory storage
Article Abstract:
Temporally graded retrograde amnesia constitutes an argument for a memory consolidation process needed for stable memory formation. Glucose uptake in selected brains areas of the mouse were mapped to measure regional metabolic activity linked with retrieval testing of a recently versus remotely acquired spatial discrimination task. The aim was to understand the roles of hippocampal formation in cortical regions during memory consolidation. It is suggested that hippocampal formation is needed to encode new information and maintain recently acquired information.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis
Article Abstract:
Memory research indicates that late-phase long-term potentiation is controlled by a postsynaptic neuronal pathway involving the synthesis of alpha-amino-three-hydroxy-five-methyl-four-isoxazole propionate receptors following protein kinase A transcription in rats. Experiments using hippocampal mini-slice preparation, subcellular fractionation, immunoprecipitation and Western blot techniques are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Space and time in the mental universe
Article Abstract:
Recent neurobiology research by J.D. Cohen et al. used magnetic resonance imaging to show the detailed temporal dynamics of working-memory functions. The results correlated with prior knowledge pertaining to perceptual and mnemonic functions in anterior and posterior association cortices. Further research is required to establish the central executive's location.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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