Rene J. Dubos and Fred L. Soper: their contrasting views on vector and disease eradication

Article Abstract:

Rene J. Dubos and Fred L. Soper, both affiliated with a Rockefeller institution, both involved in the fight for health, were in almost total opposition. Dubos worked as a microbiologist and became a very popular writer and lecturer. Soper was for much of his early professional life a public health worker in the tropics and had faith in the feasibility of disease and vector eradication. Dubos saw eradication of Anopheles gambiae from Northern Brazil and Egypt, triumphs Soper was responsible for, as atypical. Soper left a rather harsh legacy involving a severe managerial style, but his methods deserve study.

Analysis, Diseases, Beliefs, opinions and attitudes, Public health, Criticism and interpretation, Control, Vector control, Soper, Fred L.

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Changing streptococci and prospects for the global eradication of rheumatic fever

Article Abstract:

Group A Streptococci (GrAS) specifically, Streptococcus pyogenes species is a known causative agent for rheumatic fever. A major characteristic of the bacteria which accounts for their high antigenicity is the presence of epitopes in their M protein molecules that are cross-reactive to cardiac and other host tissues. Although injectable benzathine penicillin G remains to be the treatment of choice, there is still a need to develop new multivalent vaccines to catch up with inherent ability of the bacteria to undergo mutation to evade the defense mechanism of their host.

Usage, Causes of, Streptococcus pyogenes, Vaccines, Rheumatic fever

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RENE DUBOS, A HARBINGER OF MICROBIAL RESISTANCE TO ANTIBIOTICS

Article Abstract:

The article discusses the career of microbiologist Rene Dubos, who was one of the first to predict that antiobiotics may breed their own bacterial resistance. Topics include Dubos's research career, the history of bacterial resistance to drugs, and discussion of specific drugs such as penicillin and specific diseases such as tuberculosis.

United States, Antibiotics, Prevention, History, Behavior, Drug resistance in microorganisms, Microbial drug resistance, Preventive medicine, Medicine, Preventive

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