Efficiency in activation
Article Abstract:
The transcription factor IIB (TFIIB), has been recognized as an activator protein which enhances the transcription process. Recent studies have shown that TFIIB, along with the general transcription factors TFIID-TFIIJ, is important in correctly positioning the RNA polymerase II. TFIIB is transported to the complex through interactions between protein-protein binding and the TATA binding protein (TBP). Chromatography has shown thatboth TBP and TFIIB are potential targets of acidic activation domains.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus
Article Abstract:
The rotaviral double-stranded-RNA (dsRNA) has a dodecahedral structure in which the RNA double helices interact with the inner capsid layer and are packed around the enzyme complex at the icosahedral 5-fold axes. This structure helps in orchestrated movement of the RNA and the enzyme complex during transcription. This RNA is responsible for 4,500 base pairs in the genome. This virus is one of the major causes of the fatal gastroenteritis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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RNA binding and translational suppression by bicoid
Article Abstract:
The homeodomain protein bicoid (bcd) acts as a transcriptional activator and reduces the translation efficiency of BBR-containing mRNAs. Crosslinking experiments indicate that bcd binds within 120-nucleotide region of caudal (cad) mRNA, in vitro. Co-transfection experiments with Drosophila Schneider cells using phenicol acetyl transferase indicates that these proteins possess RNA-binding properties.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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